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Ingredient Analysis: Caffeoyl Hexapeptide-43

This page was last updated: 6 months ago. All information accurate at time of publishing.
Discover the dual benefits of Caffeoyl Hexapeptide-43 (pronounced: kaf-ee-oyl hexa-peptide-43), a potent antioxidant and skin-protector in cosmetics, how it's made, and its safety profile in our comprehensive guide.

What is Caffeoyl Hexapeptide-43?

Caffeoyl Hexapeptide-43 is a synthetic compound derived from the reaction of Caffeic Acid and Hexapeptide-43. Caffeic Acid is a type of polyphenol that is naturally found in many plants, while Hexapeptide-43 is a chain of six amino acids. The combination of these two components results in a potent antioxidant and skin-protecting ingredient that is used in a variety of cosmetic products.

The use of Caffeoyl Hexapeptide-43 in cosmetics is relatively recent, with its antioxidant properties being recognized and harnessed for skin care applications. It is produced through a chemical reaction where Caffeic Acid is combined with Hexapeptide-43, resulting in a compound that offers both antioxidant and skin-protecting benefits.

When compared to other similar ingredients used for the same purposes, Caffeoyl Hexapeptide-43 stands out due to its dual functionality. While many ingredients offer either antioxidant or skin-protecting benefits, Caffeoyl Hexapeptide-43 provides both. This makes it a valuable addition to cosmetic formulations, as it can help to protect the skin from environmental stressors while also providing antioxidant benefits to help maintain skin health.

Typically, Caffeoyl Hexapeptide-43 is found in a variety of skin care products, including moisturizers and serums. Its antioxidant properties make it particularly beneficial in products designed to protect the skin from environmental damage, while its skin-protecting benefits make it a valuable addition to products designed to support skin health and resilience.

Benefits and Uses

In this section, we will delve into the officially recognized benefits and uses of Caffeoyl Hexapeptide-43:

Antioxidant Properties

Caffeoyl Hexapeptide-43 is recognized for its potent antioxidant properties. In simple terms, antioxidants are substances that help protect our skin cells from damage. They work by neutralizing harmful free radicals, which are unstable molecules that can damage the cells in your skin. This damage can lead to premature aging and skin dullness. By neutralizing these free radicals, Caffeoyl Hexapeptide-43 helps to maintain the health and vitality of your skin, keeping it looking youthful and radiant.

Skin Protecting

Another key benefit of Caffeoyl Hexapeptide-43 is its skin-protecting function. This means that it helps to shield your skin from external factors that can cause damage, such as environmental pollutants and UV radiation. This protective barrier not only helps to prevent damage but also aids in maintaining the skin’s overall health and appearance. So, if you’re looking for a product that can help guard your skin against the daily onslaught of environmental stressors, look for ones that contain Caffeoyl Hexapeptide-43.

It’s important to note that these benefits are based on the officially recognized and defined functions of Caffeoyl Hexapeptide-43. There may be other potential benefits and uses of this ingredient that go beyond these functions. However, more research is needed to fully understand and validate these additional benefits.

Safety Profile

Caffeoyl Hexapeptide-43 is not a banned or regulated ingredient in cosmetics. It is generally considered safe for use in skincare and cosmetic products. However, as with any ingredient, individual reactions can vary and it is always recommended to do a patch test before widespread usage.

While Caffeoyl Hexapeptide-43 is known for its antioxidant and skin-protecting properties, potential side effects of topical application may include:

  • Minor skin irritation
  • Redness
  • Dryness

A note for women who are pregnant and/or breastfeeding – there is currently a lack of data regarding the safety of topically applied Caffeoyl Hexapeptide-43 during pregnancy or breastfeeding. As such, it is recommended to consult a healthcare professional for further advice.

Adverse reactions to Caffeoyl Hexapeptide-43 are not common, but it’s always wise to patch test a new product before applying it to a large area of skin. This can help identify any potential sensitivity or allergic reaction to the ingredient.

This ingredient analysis has been commissioned by Truth In Skincare (TiS), an independent industry regulator. The information provided has been reviewed by a TiS-appointed industry consultant, with sources including the CosIng (Cosmetic Ingredient Database – by the European Commission), the Personal Care Products Council (PCPC), The US Food & Drug Administration (FDA), as well as other various publicly available sources.