What is Cobamamide?
Cobamamide, also known as 5′-deoxyadenosylcobalamin and coenzyme B12, is a naturally occurring form of vitamin B12. It is a complex compound, the inner salt of the Co-(5′-deoxyadenosine-5′) derivative of the 3′-ester of cobinamide phosphate with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole. This ingredient is derived from the cobinamide phosphate, a derivative of vitamin B12, which is found in various food sources, particularly in animal products.
The use of Cobamamide in cosmetics is a relatively recent development. Its antioxidant, skin conditioning, and skin protecting properties have made it a popular ingredient in the cosmetic industry. The process of making Cobamamide involves complex chemical reactions, including the conversion of cobinamide phosphate into a derivative that can be combined with other compounds to form the final product.
Compared to similar ingredients used for the same purposes, Cobamamide stands out due to its unique chemical structure and its origin from vitamin B12. While other antioxidants and skin conditioners are derived from a variety of sources, Cobamamide’s vitamin B12 origin gives it a unique profile in terms of its benefits and uses.
Cobamamide is typically used in a variety of cosmetic products, including moisturizers and serums. Its antioxidant properties make it a valuable ingredient in products designed to protect the skin from environmental stressors, while its skin conditioning properties help to keep the skin smooth and hydrated. Its use in these products helps to enhance their overall effectiveness and provide additional benefits to the skin.
Benefits and Uses
In this section, we will delve into the officially recognized benefits and uses of Cobamamide:
Antioxidant
Cobamamide, as an antioxidant, plays a crucial role in protecting the skin from harmful free radicals. Free radicals are unstable molecules that can cause damage to the skin cells, leading to premature aging and other skin issues. By neutralizing these free radicals, Cobamamide helps to maintain the health and vitality of the skin, keeping it looking youthful and radiant.
Skin Conditioning
Another significant benefit of Cobamamide is its skin conditioning properties. This means it helps to enhance the appearance and feel of the skin. It works by softening and smoothing the skin, reducing roughness, cracking, and irritation. This makes the skin feel more comfortable and look more healthy and vibrant. It’s especially beneficial for those with dry or sensitive skin, as it can provide much-needed moisture and relief.
Skin Protecting
Cobamamide also serves as a skin protectant. It forms a barrier on the skin’s surface, which helps to prevent moisture loss and shields the skin from environmental stressors like pollution and harsh weather conditions. This protective layer can help to maintain the skin’s natural moisture balance, keeping it hydrated and healthy. It also helps to protect the skin from potential damage, contributing to overall skin health and resilience.
It’s important to note that these benefits are based on the officially recognized and defined functions of Cobamamide. There may be other potential benefits and uses of this ingredient that go beyond the scope of these official functions. However, these are the direct benefits that you can expect when using products containing Cobamamide.
Safety Profile
Cobamamide is not a banned or regulated ingredient in cosmetics. It is generally considered safe for use in cosmetic products. However, as with any ingredient, individual reactions can vary and it is always recommended to do a patch test before using a product containing Cobamamide widely.
While Cobamamide is generally well-tolerated, some potential side effects of topical application may include:
- Redness
- Itching
- Skin irritation
A note for women who are pregnant and/or breastfeeding – There is currently insufficient data to definitively state whether Cobamamide is safe for use during pregnancy or breastfeeding. As such, it is recommended that you consult a healthcare professional for further advice if you are pregnant or breastfeeding and considering using a product containing Cobamamide.
Adverse reactions to Cobamamide are not common, but they can occur. It is always recommended to do a patch test before using a product containing this ingredient widely to ensure you do not have an adverse reaction.
This ingredient analysis has been commissioned by Truth In Skincare (TiS), an independent industry regulator. The analysis was conducted by a TiS-appointed industry consultant, using sources including the CosIng (Cosmetic Ingredient Database – by the European Commission), the Personal Care Products Council (PCPC), The US Food & Drug Administration (FDA), as well as other various publicly available sources.
