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Ingredient Analysis: Galloyl Hexapeptide-48

This page was last updated: 6 months ago. All information accurate at time of publishing.
Unlock the secrets of Galloyl Hexapeptide-48 (pronounced gal-loyl hexa-peptide-48), a potent antioxidant and skin-protecting agent, as we delve into its origins, benefits, and safety profile in this comprehensive guide.

What is Galloyl Hexapeptide-48?

Galloyl Hexapeptide-48, also known as GH-48, is a cosmetic ingredient derived from the reaction of Gallic Acid and Hexapeptide-48. Gallic Acid is a type of phenolic acid, found in a variety of plants such as oak bark and witch hazel, while Hexapeptide-48 is a synthetic peptide composed of six amino acids. The combination of these two components results in a potent antioxidant and skin-protecting agent.

The use of Galloyl Hexapeptide-48 in cosmetics is a relatively recent development, with the ingredient gaining popularity due to its beneficial properties for skin health. The process of creating GH-48 involves a complex chemical reaction, where Gallic Acid and Hexapeptide-48 are combined under specific conditions to form the final product.

While there are other ingredients that serve similar functions as antioxidants and skin protectors, GH-48 stands out due to its unique composition. The combination of a plant-derived phenolic acid and a synthetic peptide results in a product that not only protects the skin but also has potential anti-aging benefits. This dual functionality is not commonly found in other similar ingredients.

Galloyl Hexapeptide-48 is typically used in a variety of skincare products, including moisturizers and serums. Its antioxidant properties make it an excellent addition to products designed to protect the skin from environmental stressors, while its potential anti-aging benefits make it a popular choice for products aimed at reducing the signs of aging.

Benefits and Uses

In this section, we will delve into the officially recognized benefits and uses of Galloyl Hexapeptide-48:

Antioxidant Properties

As an antioxidant, Galloyl Hexapeptide-48 is capable of neutralizing harmful free radicals in the skin. Free radicals are unstable molecules that can cause damage to the skin cells, leading to premature aging and other skin issues. By neutralizing these free radicals, Galloyl Hexapeptide-48 helps to maintain the health and vitality of the skin, keeping it looking youthful and radiant.

Skin Protecting

Another key function of Galloyl Hexapeptide-48 is its skin-protecting properties. This ingredient forms a protective barrier on the skin’s surface, shielding it from environmental stressors such as pollution, UV rays, and harsh weather conditions. This protective barrier also helps to lock in moisture, keeping the skin hydrated and preventing dryness and flaking.

It’s important to note that these benefits are based on the officially recognized and defined functions of Galloyl Hexapeptide-48. There may be other potential benefits and uses of this ingredient that go beyond the scope of these official functions. However, as consumers, it’s crucial to be aware of the direct benefits provided by this ingredient and not be misled by brands and manufacturers.

Safety Profile

Galloyl Hexapeptide-48 is not a banned or regulated ingredient in cosmetics. It is generally considered safe for use in skincare and cosmetic products. However, as with any ingredient, individual reactions can vary and it is always recommended to conduct a patch test before widespread usage.

As for its allergenic potential, Galloyl Hexapeptide-48 is not commonly associated with allergic reactions. However, individuals with sensitive skin or known allergies to peptides should exercise caution.

Potential side effects of topical application of Galloyl Hexapeptide-48 may include:

  • Minor skin irritation
  • Redness
  • Dryness

A note for women who are pregnant and/or breastfeeding – There is currently insufficient data on the safety of topical use of Galloyl Hexapeptide-48 during pregnancy or breastfeeding. As such, it is recommended to consult a healthcare professional for further advice.

Adverse reactions to Galloyl Hexapeptide-48 are not common, but it is always recommended to conduct a patch test before widespread usage to ensure no adverse reaction occurs.

This ingredient analysis has been commissioned by Truth In Skincare (TiS), an independent industry regulator. The analysis was conducted by a TiS-appointed industry consultant whose sources include CosIng (Cosmetic Ingredient Database – by the European Commission), the Personal Care Products Council (PCPC), The US Food & Drug Administration (FDA) as well as other various publicly available sources.