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Ingredient Analysis: Hexapeptide-33

This page was last updated: 6 months ago. All information accurate at time of publishing.
Unlock the secrets of Hexapeptide-33 (pronounced hexa-peptide-33), a synthetic peptide used in cosmetics, as we delve into its creation, benefits, safety, and potential side effects in this comprehensive guide.

What is Hexapeptide-33?

Hexapeptide-33 is a synthetic peptide that is commonly used in the cosmetic industry. It is composed of six amino acids: arginine, leucine, lysine, phenylalanine, serine, and tyrosine. The combination of these amino acids forms a unique peptide chain that gives Hexapeptide-33 its distinctive properties. It is also known by other names such as Palmitoyl Hexapeptide-33, which indicates the addition of a palmitic acid molecule to enhance its skin penetration capabilities.

The use of peptides in skincare products has been a relatively recent development, with Hexapeptide-33 being one of the newer additions. It was created in laboratories with the aim of harnessing the skin conditioning and protecting properties of its constituent amino acids. The production process involves the sequential linking of the amino acids in a specific order to form the Hexapeptide-33 chain.

Hexapeptide-33 shares similarities with other synthetic peptides used in skincare products, such as Matrixyl and Argireline. Like these peptides, Hexapeptide-33 is used for its skin conditioning and antioxidant properties. However, the specific combination of amino acids in Hexapeptide-33 gives it a unique profile that may offer distinct benefits.

Hexapeptide-33 is typically used in a variety of skincare products, including moisturizers and serums. Its skin conditioning properties make it a popular ingredient in products designed to hydrate and nourish the skin, while its antioxidant capabilities help to protect the skin from environmental stressors. Its versatility and potential benefits have led to its increasing popularity in the cosmetic industry.

Benefits and Uses

In this section, we will delve into the officially recognized benefits and uses of Hexapeptide-33:

Antioxidant Properties

Hexapeptide-33 is officially recognized for its antioxidant properties. In simple terms, antioxidants are substances that help protect our skin cells from damage. They do this by neutralizing harmful free radicals, which are unstable molecules that can damage the cells in your skin. This damage can lead to premature aging and other skin issues. By acting as an antioxidant, Hexapeptide-33 can help to maintain the health and appearance of your skin, and potentially slow down the aging process.

Skin Conditioning

Another recognized benefit of Hexapeptide-33 is its skin conditioning properties. This means that it helps to make the skin feel smoother, softer and more supple. It achieves this by enhancing the skin’s ability to retain moisture, which is crucial for maintaining skin health and preventing dryness and flakiness. So, if you’re looking for a product that can help to improve the texture and feel of your skin, Hexapeptide-33 could be a beneficial ingredient to look out for.

Skin Protecting

Hexapeptide-33 is also known for its skin protecting function. This means that it can help to form a barrier on the skin’s surface, which can protect it from environmental stressors such as pollution and harsh weather conditions. This protective barrier can also help to lock in moisture, further enhancing the skin’s hydration and overall health.

Please note that these benefits are based on the officially recognized functions of Hexapeptide-33, as per the CosIng Database. There may be other potential benefits and uses of this ingredient that go beyond these official functions, but for the purpose of this article, we are focusing on the direct benefits that are officially recognized and defined.

Safety Profile

Hexapeptide-33 is not a banned or regulated ingredient in cosmetics. It is generally considered safe for use in skincare and cosmetic products. However, like any ingredient, it may not be suitable for all skin types and there is always a potential for allergic reactions. It is always recommended to perform a patch test before using a new product containing Hexapeptide-33 to ensure it is suitable for your skin.

Potential side effects of topical application of Hexapeptide-33 may include:

  • Redness
  • Itching
  • Skin irritation

A note for women who are pregnant and/or breastfeeding – There is currently a lack of data regarding the safety of Hexapeptide-33 for use during pregnancy or breastfeeding. As such, it is recommended to consult a healthcare professional before using products containing this ingredient.

Adverse reactions to Hexapeptide-33 are not common, but they can occur. It is always recommended to perform a patch test before using a new product containing this ingredient to ensure it is suitable for your skin.

This ingredient analysis has been commissioned by Truth In Skincare (TiS), an independent industry regulator. The analysis was conducted by a TiS-appointed industry consultant, using sources including the CosIng (Cosmetic Ingredient Database – by the European Commission), the Personal Care Products Council (PCPC), The US Food & Drug Administration (FDA), as well as other various publicly available sources.