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Ingredient Analysis: Hexapeptide-65

This page was last updated: 5 months ago. All information accurate at time of publishing.
Discover the science behind Hexapeptide-65 (pronounced hexa-peptide-sixty-five), a revolutionary skincare ingredient known for its antioxidant and skin-protecting properties. Learn how it's made, its benefits, potential side effects, and safety profile in this comprehensive guide.

What is Hexapeptide-65?

Hexapeptide-65 is a synthetic peptide that is composed of three amino acids: alanine, lysine, and proline. This ingredient, also known as Myristoyl Hexapeptide-65, is a relatively new addition to the world of cosmetic ingredients. It is created through a process of peptide synthesis, which involves the bonding of these three amino acids in a specific sequence.

The use of peptides in skincare products has gained popularity over the years due to their ability to provide various skin benefits. Hexapeptide-65, in particular, has been recognized for its antioxidant and skin-protecting properties. It is similar to other peptides used in cosmetics, such as Matrixyl and Argireline, which are also known for their anti-aging benefits. However, Hexapeptide-65 stands out due to its unique combination of amino acids, which gives it a distinct set of properties.

Hexapeptide-65 is typically used in a variety of skincare products, including moisturizers and serums. Its antioxidant properties make it a valuable ingredient in products designed to protect the skin from environmental stressors, while its skin-protecting function makes it a beneficial addition to products aimed at improving skin health and appearance.

Benefits and Uses

In this section, we will delve into the officially recognized benefits and uses of Hexapeptide-65:

Antioxidant Properties

Hexapeptide-65 is known for its antioxidant properties. In simple terms, antioxidants are substances that help protect our cells from damage. They do this by neutralizing harmful molecules known as free radicals, which are produced in our bodies as a result of normal bodily processes and exposure to certain environmental factors. When the levels of these free radicals get too high, they can cause damage to our cells. This is where antioxidants like Hexapeptide-65 come in. They help to neutralize these free radicals, thereby protecting our cells from damage and helping to maintain the health and appearance of our skin.

Skin Protecting

Another key benefit of Hexapeptide-65 is its skin-protecting function. This means that it helps to protect the skin from various forms of damage. This could include environmental damage, such as exposure to harmful UV rays, as well as damage caused by the natural aging process. By helping to protect the skin in this way, Hexapeptide-65 can help to maintain the skin’s health and appearance, and may even help to prevent signs of aging such as wrinkles and fine lines.

It’s important to note that the benefits listed above are based on the officially recognized and defined functions of Hexapeptide-65. There may be other benefits and uses of this ingredient that go beyond the scope of these official functions. However, these additional benefits are not officially recognized and therefore cannot be guaranteed.

Safety Profile

Hexapeptide-65 is not a banned or regulated ingredient in cosmetics. It is generally considered safe for use in skincare and cosmetic products. However, like any ingredient, it may not be suitable for all skin types and there is always a potential for allergic reactions.

Possible side effects of topical application of Hexapeptide-65 include:

  • Redness
  • Itching
  • Skin irritation

A note for women who are pregnant and/or breastfeeding – There is currently insufficient data available to definitively state whether Hexapeptide-65 is safe for use during pregnancy or breastfeeding. As such, it is recommended that you consult with a healthcare professional before using products containing this ingredient.

Adverse reactions to Hexapeptide-65 are not common, but as with any new skincare product, it is recommended to perform a patch test before widespread usage to ensure you do not have an adverse reaction.

This ingredient analysis has been commissioned by Truth In Skincare (TiS), an independent industry regulator. The analysis was conducted by a TiS-appointed industry consultant, using sources including the CosIng (Cosmetic Ingredient Database – by the European Commission), the Personal Care Products Council (PCPC), The US Food & Drug Administration (FDA) as well as other various publicly available sources.