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Ingredient Analysis: Nicotinoyl Hexapeptide-44

This page was last updated: 5 months ago. All information accurate at time of publishing.
Unlock the secrets of Nicotinoyl Hexapeptide-44 (pronounced: Nee-co-tin-oyl Hexa-peptide-44), a synthetic compound with antioxidant and skin-protecting properties, learn how it's made, what it does, and its safety profile in our comprehensive guide.

What is Nicotinoyl Hexapeptide-44?

Nicotinoyl Hexapeptide-44 is a synthetic compound derived from the reaction of Niacin, also known as Vitamin B3, and Hexapeptide-44. This unique compound is also known by its other name, Niacinamide Hexapeptide-44, and is characterized by its complex chemical structure that combines the antioxidant properties of Niacin and the skin-protecting capabilities of Hexapeptide-44.

The use of Nicotinoyl Hexapeptide-44 in cosmetic products is a relatively recent development. The compound was first synthesized in laboratories as part of ongoing research into the benefits of peptides and vitamins for skin health. Recognizing its potential, cosmetic scientists began incorporating it into various skincare formulations, where it quickly gained popularity for its beneficial effects.

The production of Nicotinoyl Hexapeptide-44 involves a chemical reaction between Niacin and Hexapeptide-44. This process is carried out in controlled laboratory conditions to ensure the purity and effectiveness of the final product. The resulting compound is a stable, water-soluble ingredient that can be easily incorporated into various cosmetic formulations.

While there are other ingredients that share similar antioxidant and skin-protecting functions, such as Vitamin C or Retinol, Nicotinoyl Hexapeptide-44 stands out due to its unique combination of these properties. Unlike these other ingredients, Nicotinoyl Hexapeptide-44 is a peptide-based compound, which allows it to penetrate the skin more effectively and deliver its benefits more directly.

Typically, you can find Nicotinoyl Hexapeptide-44 in a variety of skincare products, including moisturizers, serums, and anti-aging creams. Its versatile nature and beneficial properties make it a popular choice for brands seeking to enhance the effectiveness of their products and deliver noticeable results to their customers.

Benefits and Uses

In this section, we will delve into the officially recognized benefits and uses of Nicotinoyl Hexapeptide-44:

Antioxidant Properties

One of the primary benefits of Nicotinoyl Hexapeptide-44 is its antioxidant properties. In layman’s terms, an antioxidant is a substance that helps protect our skin cells from damage. This damage, often caused by harmful molecules known as free radicals, can lead to premature aging and various skin issues. By neutralizing these free radicals, Nicotinoyl Hexapeptide-44 helps to maintain the health and vitality of the skin, keeping it looking youthful and radiant.

Skin Protecting

Another key function of Nicotinoyl Hexapeptide-44 is its ability to protect the skin. This ingredient forms a protective barrier on the skin’s surface, shielding it from environmental stressors such as pollution, UV rays, and harsh weather conditions. This protective function helps to prevent skin damage and maintain the skin’s overall health and appearance. It’s like a shield for your skin, guarding it against external threats that can cause harm.

It’s important to note that the benefits listed above are based on the officially recognized and defined functions of Nicotinoyl Hexapeptide-44. There may be other benefits and uses of this ingredient that go beyond the scope of these official functions. However, as consumers, it’s crucial to be aware of the direct benefits provided by this ingredient, so as not to be misled by brands and manufacturers.

Safety Profile

Nicotinoyl Hexapeptide-44 is not a banned or regulated ingredient in cosmetics. It is generally considered safe for use in skincare and cosmetic products. However, as with any ingredient, individual reactions can vary and it is always recommended to do a patch test before using any new product widely.

As an antioxidant and skin-protecting ingredient, Nicotinoyl Hexapeptide-44 is not known to have a high allergenic potential. However, potential side effects of topical application of this ingredient may include:

  • Minor skin irritation
  • Redness
  • Dryness

A note for women who are pregnant and/or breastfeeding – there is currently a lack of data regarding the safety of topical usage of Nicotinoyl Hexapeptide-44 during pregnancy or breastfeeding. As such, it is recommended to consult a healthcare professional for further advice.

Adverse reactions to Nicotinoyl Hexapeptide-44 are not common, but as mentioned earlier, it is always recommended to do a patch test before using any new product widely.

This ingredient analysis has been commissioned by Truth In Skincare (TiS), an independent industry regulator. The analysis was conducted by a TiS-appointed industry consultant, using sources that include the CosIng (Cosmetic Ingredient Database – by the European Commission), the Personal Care Products Council (PCPC), The US Food & Drug Administration (FDA), as well as other various publicly available sources.