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Ingredient Analysis: Pentapeptide-27

This page was last updated: 6 months ago. All information accurate at time of publishing.
Uncover the science behind Pentapeptide-27 (pronounced pen-ta-pep-tide-twenty-seven), a potent skincare ingredient, as we delve into its creation, unique properties, benefits, and safety profile in this comprehensive guide.

What is Pentapeptide-27?

Pentapeptide-27, also known as Matrixyl synthe’6, is a synthetic peptide that is widely used in the cosmetic industry. This ingredient is composed of five amino acids: cysteine, glutamic acid, glycine, lysine, and threonine. These amino acids are combined in a specific sequence to create the unique structure of Pentapeptide-27.

The use of Pentapeptide-27 in cosmetics is a relatively recent development. It was created in a laboratory setting with the goal of providing a potent and effective ingredient for skincare products. The process of making Pentapeptide-27 involves the careful combination of its constituent amino acids in a controlled environment to ensure the correct formation of the peptide.

While there are many peptides used in skincare, Pentapeptide-27 stands out due to its specific combination of amino acids. Other peptides may share some of the same amino acids, but the unique sequence in Pentapeptide-27 is what gives it its particular properties. It’s important to note that while Pentapeptide-27 shares some similarities with other peptides, it should not be confused with them. Each peptide has its own unique properties and benefits.

Pentapeptide-27 is typically found in a variety of skincare products, including moisturizers and serums. Its antioxidant, chelating, and skin-protecting properties make it a valuable addition to these products. It is particularly beneficial in products designed to combat the signs of aging, as it can help to protect the skin from damage and maintain its youthful appearance.

Benefits and Uses

In this section, we will delve into the officially recognized benefits and uses of Pentapeptide-27:

Antioxidant

Pentapeptide-27 serves as an antioxidant in cosmetic products. In layman’s terms, it helps to protect the skin from damage caused by harmful molecules known as free radicals. These free radicals can be produced by various environmental factors such as pollution, sunlight, and smoke. By neutralizing these free radicals, Pentapeptide-27 helps to maintain the health and vitality of the skin, preventing premature aging and promoting a youthful appearance.

Chelating

Another official function of Pentapeptide-27 is its chelating property. Chelating agents are substances that can bind to and neutralize metal ions, which can be harmful to the skin. In the context of cosmetics, this means that Pentapeptide-27 can help to remove potentially harmful metals from the skin, thereby enhancing the overall effectiveness of the product and improving skin health.

Skin Protecting

Pentapeptide-27 also plays a crucial role in skin protection. It helps to strengthen the skin’s natural barrier, thereby shielding it from environmental stressors such as UV rays and pollution. This protective function helps to keep the skin healthy and resilient, reducing the risk of skin problems such as dryness, redness, and irritation.

It’s important to note that these benefits are based on the officially recognized and defined functions of Pentapeptide-27. There may be other benefits and uses of this ingredient that go beyond the scope of these official functions. However, these additional benefits are not officially recognized and should be considered with caution.

Safety Profile

Pentapeptide-27 is not a banned or regulated ingredient in cosmetics. It is generally considered safe for use in cosmetic products. However, as with any ingredient, individual reactions can vary and it is always recommended to perform a patch test before widespread usage.

As for its allergenic potential, Pentapeptide-27 is not typically known to cause allergic reactions. However, individuals with sensitive skin or known allergies to peptides should exercise caution.

Potential side effects of topical application of Pentapeptide-27 may include:

  • Minor skin irritation
  • Redness
  • Dryness

A note for women who are pregnant and/or breastfeeding – There is currently insufficient data on the safety of topical use of Pentapeptide-27 during pregnancy or breastfeeding. As such, it is recommended that you consult a healthcare professional for further advice.

Adverse reactions to Pentapeptide-27 are not common, but as mentioned earlier, individual reactions can vary. It is always recommended to perform a patch test before widespread usage to ensure there is no adverse reaction.

This ingredient analysis has been commissioned by Truth In Skincare (TiS), an independent industry regulator. The analysis was performed by a TiS-appointed industry consultant whose sources include CosIng (Cosmetic Ingredient Database – by the European Commission), the Personal Care Products Council (PCPC), The US Food & Drug Administration (FDA) as well as other various publicly available sources.