What is Sh-Octapeptide-4?
Sh-Octapeptide-4 is a synthetic peptide, designed to mimic the human protein Enkephalin. This ingredient is a complex of eight amino acids, namely glycine, histidine, leucine, lysine, phenylalanine, and tyrosine. The ‘SH’ in its name refers to the presence of a sulfhydryl group, a sulfur and hydrogen atom, which is a common component in many biological compounds.
The use of Sh-Octapeptide-4 in cosmetics is a relatively recent development, stemming from advancements in biotechnology and our understanding of human biochemistry. It was discovered that certain peptides, like Enkephalin, have beneficial effects on the skin, leading to the development of synthetic versions for use in cosmetic products.
Sh-Octapeptide-4 is produced through a process known as recombinant DNA technology. This involves inserting the DNA sequence that codes for the Enkephalin protein into a host organism, usually bacteria or yeast, which then produces the peptide. This method allows for large scale production of the peptide in a controlled and consistent manner.
While there are many peptides used in cosmetics, Sh-Octapeptide-4 stands out due to its specific combination of amino acids. This unique composition allows it to perform a variety of functions, including acting as an anti-seborrheic, antioxidant, chelating agent, reducing agent, and skin protectant. This multifunctionality sets it apart from other peptides, which may only perform one or two functions.
Typically, Sh-Octapeptide-4 is found in a variety of skincare products, such as moisturizers and serums. Its versatile nature makes it a valuable addition to these products, enhancing their ability to protect and nourish the skin.
Benefits and Uses
In this section, we will delve into the officially recognized benefits and uses of Sh-Octapeptide-4:
Anti-Seborrheic
Sh-Octapeptide-4 is recognized for its anti-seborrheic properties. In layman’s terms, this means it can help control the production of sebum, the oily substance produced by our skin’s sebaceous glands. Excessive sebum production can lead to oily skin and acne. By regulating sebum production, Sh-Octapeptide-4 can help maintain a balanced, healthy skin appearance.
Antioxidant
As an antioxidant, Sh-Octapeptide-4 can protect the skin from damage caused by free radicals. Free radicals are unstable molecules that can cause harm to our cells, leading to premature aging and skin damage. By neutralizing these free radicals, Sh-Octapeptide-4 helps to maintain the skin’s youthful appearance and vitality.
Chelating
Sh-Octapeptide-4 also has chelating properties. This means it can bind to metal ions, preventing them from contributing to chemical reactions that could damage the skin. This is particularly beneficial in protecting the skin from environmental pollutants and toxins.
Reducing
The reducing function of Sh-Octapeptide-4 refers to its ability to donate electrons to other molecules. This process can help to stabilize potentially harmful molecules and reduce their reactivity, thereby protecting the skin from oxidative stress and potential damage.
Skin Protecting
Finally, Sh-Octapeptide-4 is recognized for its skin-protecting properties. It can help to strengthen the skin’s natural barrier, protecting it from external factors such as environmental pollutants and UV radiation. This can help to maintain the skin’s overall health and appearance.
It’s important to note that these benefits are based on the officially recognized and defined functions of Sh-Octapeptide-4. There may be other benefits and uses of this ingredient that go beyond the scope of these official functions.
Safety Profile
SH-Octapeptide-4 is not a banned or regulated ingredient in cosmetics. It is generally considered safe for use in skincare products. However, as with any cosmetic ingredient, individual reactions can vary. It is always recommended to conduct a patch test before using a new product containing SH-Octapeptide-4 to ensure no adverse reactions occur.
While SH-Octapeptide-4 is generally well-tolerated, potential side effects of topical application could include:
- Redness
- Itching
- Skin irritation
A note for women who are pregnant and/or breastfeeding – there is currently limited data on the safety of SH-Octapeptide-4 during pregnancy or breastfeeding. As such, it is recommended to consult a healthcare professional before using products containing this ingredient during these periods.
Adverse reactions to SH-Octapeptide-4 are not common, but as mentioned earlier, individual reactions can vary. It is always best to conduct a patch test before using a new product containing this ingredient to ensure no adverse reactions occur.
This ingredient analysis has been commissioned by Truth In Skincare (TiS), an independent industry regulator. The analysis was conducted by a TiS-appointed industry consultant, using sources including the CosIng (Cosmetic Ingredient Database – by the European Commission), the Personal Care Products Council (PCPC), The US Food & Drug Administration (FDA), as well as other various publicly available sources.
