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Ingredient Analysis: Tocophereth-50

This page was last updated: 6 months ago. All information accurate at time of publishing.
Dive into the world of Tocophereth-50 (pronounced toh-koh-fair-eth-50), a unique Vitamin E derivative used in cosmetics, and discover its creation, benefits, and safety profile in our comprehensive guide.

What is Tocophereth-50?

Tocophereth-50, also known as 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol, ethoxylated (50 mol EO average molar ratio), is a synthetic ingredient derived from Vitamin E. It is a complex mixture of polyethylene glycol ethers of mixed tocopherols (Vitamin E), and its chemical composition makes it a unique and versatile ingredient in the cosmetic industry.

The use of Tocophereth-50 in cosmetics dates back several decades, with its antioxidant properties being the primary reason for its inclusion in many formulations. It is created through a process known as ethoxylation, where ethylene oxide is added to the molecule, increasing its water solubility and enhancing its ability to penetrate the skin.

While there are other Vitamin E derivatives used in cosmetics, such as Tocopherol and Tocopheryl Acetate, Tocophereth-50 stands out due to its higher ethoxylation level. This makes it more water-soluble and allows it to provide a deeper level of skin conditioning and cleansing.

Typically, Tocophereth-50 is used in a wide range of cosmetic products, including moisturizers, serums, cleansers, and anti-aging treatments. Its antioxidant properties help protect the skin from environmental stressors, while its skin conditioning and cleansing abilities contribute to a smoother, healthier complexion.

Benefits and Uses

In this section, we will delve into the officially recognized benefits and uses of Tocophereth-50:

Antioxidant Properties

As an antioxidant, Tocophereth-50 plays a crucial role in protecting the skin from harmful free radicals. Free radicals are unstable molecules that can cause damage to your skin cells, leading to premature aging and other skin issues. By neutralizing these free radicals, Tocophereth-50 helps to maintain the health and vitality of your skin, keeping it looking youthful and radiant.

Skin Conditioning

Tocophereth-50 is also known for its skin conditioning properties. This means it helps to make the skin feel smoother, softer, and more supple. It achieves this by enhancing the skin’s natural moisture barrier, preventing the loss of hydration and ensuring your skin stays moisturized and nourished. This can result in a more even skin texture and an overall improved skin appearance.

Cleansing Abilities

Another official function of Tocophereth-50 is its cleansing ability. It aids in the removal of dirt, oils, and other impurities from the skin’s surface. This can help to prevent clogged pores, which can lead to breakouts and other skin issues. By effectively cleansing the skin, Tocophereth-50 can contribute to a clearer, healthier-looking complexion.

It’s important to note that these benefits are based on the officially recognized and defined functions of Tocophereth-50. There may be other benefits and uses of this ingredient that go beyond the scope of these official functions. However, these additional benefits are not officially recognized and should be considered with caution until further research is conducted.

Safety Profile

Tocophereth-50 is not a banned or regulated ingredient in cosmetics. It is generally considered safe for use in cosmetic products. However, like any ingredient, it may not be suitable for all skin types and conditions. It is always recommended to conduct a patch test before using any new product containing this ingredient.

While Tocophereth-50 has antioxidant, skin conditioning, and cleansing properties, it is not without potential side effects. These may include:

  • Minor skin irritation
  • Allergic reactions in individuals with sensitivity to the ingredient

A note for women who are pregnant and/or breastfeeding – there is currently insufficient data on the safety of topically applied Tocophereth-50 during pregnancy or breastfeeding. As such, it is recommended to consult a healthcare professional for further advice.

Adverse reactions to Tocophereth-50 are not common, but they can occur, particularly in individuals with sensitive skin or allergies to the ingredient. It is always recommended to conduct a patch test before using any new product containing this ingredient.

This ingredient analysis has been commissioned by Truth In Skincare (TiS), an independent industry regulator. The analysis was conducted by a TiS-appointed industry consultant, using sources including the CosIng (Cosmetic Ingredient Database – by the European Commission), the Personal Care Products Council (PCPC), The US Food & Drug Administration (FDA), as well as other various publicly available sources.